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and adaptation. Second are the neurodevelopmental stages that parallel the evolutionary progression. Third is the content of personality characteristics. Here we draw on the distinction between function and structure made in the biological sciences. Anatomy is concerned with permanent structures, and physiology is concerned with the functions that these structures permit. The anatomy of the hand, for example, is composed of bone, muscle, and nerves, and the function of a hand is manual manipulation. Likewise, the structural domains of personality provide essentially permanent substrates that provide hardware support for the functional domains of personality, that is, behaviors, social conduct, cognitive processes, and unconscious mechanisms that manage, balance, and coordinate the give-and-take between inner and outer life. Figure 2.5 shows the relationship among personality, its perspectives, and their domains. The following paragraphs provide a brief exposition of the characteristic domains that we draw on in later chapters.

Research on speci c academic interventions for children with epilepsy was not identi ed. With potential side effects of medications and seizure disorder both impacting on speed of processing as well as fatigue, it is important to consider modi cation of time allowances or reduction of workload for students with seizure disorders. Many parents, particularly those from higher socioeconomic levels, express concern with the lack of appropriate knowledge and educational services (K. N. Wu et al., 2008). In-service or educational information for staff, teachers, and students who work and interact with a child with a seizure disorder, as well as for the child and family members, may increase their level of comfort and ease, ultimately improving the outcome for the child. A study of the effects of an epilepsy education program indicated that children who participated in the educational intervention demonstrated an increase in knowledge and positive attitude about epilepsy as compared to control counterparts (Martinuik, Speechley, Seeco, Campbell, & Donner, 2007). For many individuals, changes may be needed in level of intervention or type of intervention as physiological changes occur. For this reason, frequent monitoring of progress and data-based decision making are needed whenever an intervention (medical, psychological, or educational) is instituted due to potential changes in functioning over time.

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Support good practices normatively. Enforce compliance with the rules Exercise control over behaviour through teaching and its inscription in the premises of action Maintain equilibrium among the parameters of effectiveness, ef ciency and reliability Safety, like an accident, is a cost

sis in these areas, perhaps because of skepticism about the ability of pharmacogenomics to increase business, and some claim, from fear of revealing otherwise unknown side effects and risks that would actually hamstring regulatory approval efforts (Longman, 2001) Some believe that large drug companies may shy away from risks associated with fragmentation of the market, whereby target populations for their drugs are winnowed by identi cation and characterization of disease subpopulations, dampening the blockbuster market impact of their drugs (Longman, 2001; Ma, 2001) Although most of what the pharmaceutical industry fears lies at the heart of the intended human bene ts of pharmacogenomics, these economic uncertainties and risks have thwarted efforts of pharmacogenomics advocates to inject pharmacogenomic analysis into the near-term agendas of Big Pharma (Longman, 2001) The importance and potential of pharmacogenomics, however, are not lost on the broader pharmaceutical industry.

Current thresholds:

The structure of the Half-Sync/Half-Async pattern follows the Layers pattern [POSA1] and includes four participants: The synchronous service layer performs high-level processing services. Services in the synchronous layer run in separate threads or processes that can block while performing operations.

Despite declining to make use of pharmacogenomic technology in present clinical trials, some Big Pharma players are banking clinical samples for retrospective analysis (Longman, 2001) The preferred role that pharmaceutical companies envision for pharmacogenomics lies as part of an integrated discovery program that utilizes pharmacogenomic analysis to head off tremendous development costs for drugs that would later die anyway and to focus on target populations for increased ef cacy (Longman, 2001) Integration of pharmacogenomic techniques in discovery and at earlier stages in the development process does not inhere risks to development investments already made for late-stage compounds, and the use of pharmacogenomics in discovery and early stages in which speculation is an accepted part of the process is a much easier sell for unproven pharmacogenomic technology (Longman, 2001).

FIGURE 14.12 Effects of amplitude and phase errors and element failure on the depth of the first null of the 20-element array of Figure 14.11.

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